Protein localization to plasma membrane raft

Across TCGA patient cohorts, RNA activity of the Protein localization to plasma membrane raft pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNX9, TUBB6, and FLNA_S2414, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane raft activity versus SNX9 in COAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNX9 →	+0.295	+0.079	<.001	<.001	3	9
UCEC	TUBB6 →	+0.595	+0.169	<.001	<.001	3	9
BRCA	FLNA_S2414 →	+0.621	+0.080	<.001	<.001	3	9
GBM	LUM →	+0.950	+0.088	<.001	<.001	3	9
BRCA	EHD2 →	+0.894	+0.098	<.001	<.001	3	9
BRCA	KANK2 →	+0.705	+0.111	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044860 vs SNX9 — COAD

Explore this scatter interactively →