Protein localization to plasma membrane raft

Across TCGA patient cohorts, RNA activity of the Protein localization to plasma membrane raft pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPA14, ATP1B1, and ATL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane raft activity versus HSPA14 in BRCA (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPA14 →	-0.404	-0.227	<.001	<.001	3	5
UCEC	ATP1B1 →	+0.817	+0.141	<.001	<.001	3	5
UCEC	ATL3 →	+0.461	+0.110	<.001	<.001	3	4
PDAC	STING1 →	+0.481	+0.148	<.001	<.001	3	4
BRCA	BCAP31 →	+0.719	+0.180	<.001	<.001	2	5
UCEC	VANGL1 →	+0.553	+0.133	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044860 vs HSPA14 — BRCA

Explore this scatter interactively →