Protein localization to plasma membrane raft

Across TCGA cell cohorts, RNA activity of the Protein localization to plasma membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRB, SLC4A2, and FAM228B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRB grouped by Protein localization to plasma membrane raft-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PTPRB →	-2.035	-1.626	<.001	<.001	3	4
SOFT_TISSUE	SLC4A2 →	+0.967	+1.055	.006	.003	3	4
PANCREAS	FAM228B →	+1.134	+1.401	.004	.003	3	4
PANCREAS	RTL5 →	+1.336	+1.608	.006	.001	3	4
LARGE_INTESTINE	F2R →	+1.353	+0.956	.005	.002	3	3
LIVER	MYOF →	-4.826	-1.376	<.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRB by Protein localization to plasma membrane raft activity — STOMACH

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