Protein localization to plasma membrane raft

Across TCGA cell cohorts, RNA activity of the Protein localization to plasma membrane raft pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP1B1, THOC5, and ITM2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to plasma membrane raft activity versus ATP1B1 in CNS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ATP1B1 →	+1.293	+0.433	<.001	<.001	3	6
OVARY	THOC5 →	-0.982	-0.379	<.001	<.001	3	4
OVARY	ITM2B →	+1.566	+0.452	.001	<.001	3	4
LARGE_INTESTINE	POLR1E →	-0.760	-0.283	.002	<.001	3	4
PANCREAS	ZNF311 →	+1.039	+0.358	<.001	<.001	3	4
CNS	NAP1L1 →	-0.584	-0.256	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044860 vs ATP1B1 — CNS

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