Plasma membrane raft organization

Across TCGA cell cohorts, RNA activity of the Plasma membrane raft organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACSIN2, CAPN1, and FLOT1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane raft organization activity versus PACSIN2 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PACSIN2 →	+1.067	+0.269	<.001	<.001	3	7
OESOPHAGUS	CAPN1 →	+1.252	+0.178	<.001	.001	3	6
BLOOD_Lymphoma	FLOT1 →	+2.176	+0.364	<.001	<.001	3	5
BLOOD_Lymphoma	FLOT2 →	+1.543	+0.284	.002	<.001	3	5
LUNG_SCLC	POLDIP3 →	+0.563	+0.179	.002	.007	3	5
LARGE_INTESTINE	ZC3H7B →	+0.881	+0.265	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044857 vs PACSIN2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →