Plasma membrane raft assembly

Across TCGA patient cohorts, RNA activity of the Plasma membrane raft assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNW1, CHAF1A_S141, and TNS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane raft assembly activity versus SNW1 in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNW1 →	-0.188	-0.060	<.001	<.001	3	7
OV	CHAF1A_S141 →	-0.744	-0.074	.001	.001	3	7
COAD	TNS2 →	+0.358	+0.041	<.001	.004	3	7
LSCC	TNS2_S941 →	+0.371	+0.080	.004	.006	3	7
GBM	CAV1 →	+1.100	+0.170	<.001	<.001	3	7
BRCA	CAV1_S37 →	+0.941	+0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044854 vs SNW1 — BRCA

Explore this scatter interactively →