Plasma membrane raft assembly

Across TCGA patient cohorts, RNA activity of the Plasma membrane raft assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRGPRF, SRPX, and CAV1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane raft assembly activity versus MRGPRF in BRCA (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MRGPRF →	+0.587	+0.189	<.001	<.001	3	6
BRCA	SRPX →	+1.213	+0.241	<.001	<.001	3	5
GBM	CAV1 →	+1.513	+0.502	<.001	<.001	3	5
BRCA	F13A1 →	+1.207	+0.196	<.001	<.001	3	5
BRCA	JAM2 →	+0.741	+0.218	<.001	<.001	3	5
UCEC	TWIST2 →	+1.108	+0.122	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044854 vs MRGPRF — BRCA

Explore this scatter interactively →