Plasma membrane raft assembly

Across TCGA cell cohorts, RNA activity of the Plasma membrane raft assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRICKLE1, FOXO6, and CD46, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRICKLE1 grouped by Plasma membrane raft assembly-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PRICKLE1 →	+2.428	+1.515	.001	<.001	3	4
LIVER	FOXO6 →	+0.805	+1.348	.007	<.001	3	4
SKIN	CD46 →	+0.588	+1.230	.001	<.001	2	5
BLOOD_Myeloma	MSRB2 →	+1.653	+1.404	.002	.003	3	4
SOFT_TISSUE	SLC6A6 →	-1.493	-1.435	.001	.009	2	5
LARGE_INTESTINE	LPIN1 →	-1.132	-0.830	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRICKLE1 by Plasma membrane raft assembly activity — LIVER

Explore this box plot interactively →