Plasma membrane raft assembly

Across TCGA cell cohorts, RNA activity of the Plasma membrane raft assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PACSIN2, CATSPER1, and ZC3H7B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane raft assembly activity versus PACSIN2 in BREAST (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PACSIN2 →	+1.004	+0.269	<.001	.001	2	8
OVARY	CATSPER1 →	+1.691	+0.287	.003	.001	3	6
LARGE_INTESTINE	ZC3H7B →	+0.825	+0.256	.001	.001	3	5
BLOOD_Leukemia	PDLIM7 →	+0.787	+0.195	.005	.005	3	5
BLOOD_Lymphoma	FLOT1 →	+2.175	+0.354	<.001	<.001	3	5
OESOPHAGUS	TRIOBP →	+0.956	+0.146	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044854 vs PACSIN2 — BREAST

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