Hair cycle phase

pathway activity — cross-omics
GO:0044851Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Hair cycle phase pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLT3, GLRX, and XBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCFLT3 →-0.405-0.193.005.00735
COADGLRX →-0.570-0.692.003.00235
BRCAXBP1 →-1.284-0.216.003.00234
LSCCCD9 →+0.874+0.253<.001<.00134
LSCCSQLE →+0.528+0.249.002<.00134
HNSCCD79A →-1.253-0.181.003<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration