Estrous cycle

Across TCGA patient cohorts, RNA activity of the Estrous cycle pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, C1R, and EMILIN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Estrous cycle activity versus THBS3 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	THBS3 →	+0.713	+0.091	<.001	<.001	3	8
OV	C1R →	+0.822	+0.090	<.001	<.001	3	8
HNSC	EMILIN1 →	+0.388	+0.082	<.001	<.001	3	8
BRCA	SERPING1 →	+0.505	+0.061	<.001	<.001	3	8
BRCA	DCN →	+0.924	+0.086	<.001	<.001	3	8
GBM	MRC2 →	+0.738	+0.126	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044849 vs THBS3 — BRCA

Explore this scatter interactively →