Biological phase

pathway activity — cross-omics
GO:0044848Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Biological phase pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KRT80, KRT23, and CTNNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCKRT80 →+1.028+0.106<.001<.00136
BRCAKRT23 →+1.073+0.080<.001<.00136
UCECCTNNB1 →+0.336+0.111<.001.00235
UCECRCN2 →+0.405+0.105<.001<.00135
LSCCITGB4 →+0.528+0.073<.001<.00135
LSCCBTK →-0.362-0.080<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration