Biological phase

pathway activity — cross-omics
GO:0044848Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Biological phase pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM158, GLRX, and ZBTB7C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCTMEM158 →+1.088+0.262<.001<.00135
COADGLRX →-0.551-0.702.004.00234
LSCCZBTB7C →+1.135+0.245<.001<.00134
LSCCSQLE →+0.536+0.250.001<.00134
LSCCCARD8 →-0.526-0.296<.001<.00134
LSCCCGREF1 →+0.710+0.162<.001.00334
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration