Biological phase

pathway activity — cross-omics
GO:0044848Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Biological phase pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CTNNB1, DSP_S22, and FAM114A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACTNNB1 →+0.368+0.170<.001<.00135
HNSCDSP_S22 →+0.749+0.187<.001.00134
OVFAM114A2 →-0.299-0.263<.001.00234
HNSCDOCK8 →-0.404-0.141<.001<.00134
HNSCDSC2 →+0.788+0.208<.001<.00134
OVRGS14_S218 →-0.669-0.235.002<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration