Cell cycle G1/S phase transition

Across TCGA cell cohorts, RNA activity of the Cell cycle G1/S phase transition pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THAP9, YTHDF2, and AKR7A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle G1/S phase transition activity versus THAP9 in SKIN (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	THAP9 →	+0.298	+0.118	.004	.003	3	6
SOFT_TISSUE	YTHDF2 →	+0.833	+0.267	.001	.005	3	5
OVARY	AKR7A3 →	+0.547	+0.244	<.001	<.001	3	5
BLOOD_Leukemia	ST3GAL6 →	-2.162	-0.168	.003	.002	3	4
LUNG_SCLC	DHODH →	+0.616	+0.167	.002	.001	3	4
BREAST	KIF1B →	+0.772	+0.161	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044843 vs THAP9 — SKIN

Explore this scatter interactively →