Cell cycle G2/M phase transition

Across TCGA patient cohorts, RNA activity of the Cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POP1, CENPF, and CKS2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle G2/M phase transition activity versus POP1 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	POP1 →	+0.989	+1.265	<.001	<.001	3	3
BRCA	CENPF →	+1.850	+1.145	.001	.002	3	3
BRCA	CKS2 →	+0.958	+0.966	.001	<.001	3	3
BRCA	NUF2 →	+1.310	+0.851	.005	.001	3	3
BRCA	EXO1 →	+1.450	+1.121	.005	.003	3	3
BRCA	CDCA2 →	+2.457	+1.341	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044839 vs POP1 — BRCA

Explore this scatter interactively →