Cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLYBL, TMBIM1, and SERTAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLYBL grouped by Cell cycle G2/M phase transition-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CLYBL →	-1.082	-0.259	.004	.001	3	5
OESOPHAGUS	TMBIM1 →	+1.203	+0.184	.002	<.001	3	5
OESOPHAGUS	SERTAD1 →	+1.383	+0.261	.003	.001	3	4
CNS	RRAGD →	-2.030	-0.259	.001	.004	3	4
OESOPHAGUS	CNTN1 →	-2.578	-0.208	.003	.002	3	4
OESOPHAGUS	RANGRF →	-1.148	-0.198	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLYBL by Cell cycle G2/M phase transition activity — KIDNEY

Explore this box plot interactively →