Cell cycle G2/M phase transition

Across TCGA cell cohorts, RNA activity of the Cell cycle G2/M phase transition pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRT1, WEE1, and FAM53B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell cycle G2/M phase transition activity versus SIRT1 in BREAST (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SIRT1 →	+0.696	+1.012	.001	<.001	3	7
LIVER	WEE1 →	+1.096	+1.252	.002	.003	2	6
SKIN	FAM53B →	+1.005	+0.990	<.001	.001	3	5
BLOOD_Leukemia	ZNF100 →	+1.274	+0.444	<.001	.004	3	5
SOFT_TISSUE	RSBN1L →	+0.706	+1.370	.002	.002	3	5
SOFT_TISSUE	ZNF527 →	+0.546	+1.600	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044839 vs SIRT1 — BREAST

Explore this scatter interactively →