Actomyosin contractile ring organization

Across TCGA patient cohorts, RNA activity of the Actomyosin contractile ring organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRTC1, AP2S1, and VKORC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actomyosin contractile ring organization activity versus CRTC1 in HNSC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CRTC1 →	-0.732	-0.229	<.001	<.001	3	5
LUAD	AP2S1 →	+0.415	+0.242	<.001	.001	3	5
OV	VKORC1 →	+0.471	+0.898	<.001	<.001	3	5
HNSC	CAVIN1 →	+0.647	+0.177	.006	.001	3	5
PDAC	YWHAZ →	+0.346	+0.381	.007	.007	3	5
PDAC	TMEM158 →	+0.973	+0.503	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044837 vs CRTC1 — HNSC

Explore this scatter interactively →