Actomyosin contractile ring organization

Across TCGA cell cohorts, RNA activity of the Actomyosin contractile ring organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC6, RNF165, and WDR47, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC6 grouped by Actomyosin contractile ring organization-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CCDC6 →	+1.026	+0.421	<.001	<.001	3	4
BONE	RNF165 →	-1.292	-0.474	.004	.001	3	3
BONE	WDR47 →	-0.666	-0.451	.007	.003	3	3
KIDNEY	C4orf19 →	+1.431	+0.694	.001	.007	3	3
KIDNEY	NCK1 →	+0.742	+0.732	<.001	.004	3	3
KIDNEY	MUC20 →	+1.013	+0.702	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC6 by Actomyosin contractile ring organization activity — LUNG_SCLC

Explore this box plot interactively →