Modulation by host of viral RNA genome replication

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LIHC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FMR1, TMEM41B, and STAG2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral RNA genome replication activity versus FMR1 in LIHC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	FMR1 →	+0.940	+0.072	<.001	<.001	3	28
UVM	TMEM41B →	+0.768	+0.045	<.001	<.001	3	27
DLBC	STAG2 →	+0.852	+0.045	<.001	.001	3	24
UVM	FAM199X →	+0.920	+0.045	<.001	<.001	3	24
UVM	ALG13 →	+0.642	+0.041	<.001	<.001	3	23
DLBC	OGT →	+1.139	+0.045	.001	.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044830 vs FMR1 — LIHC

Explore this scatter interactively →