Modulation by host of viral RNA genome replication

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAGED2, FMR1, and AFM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral RNA genome replication activity versus MAGED2 in BRCA (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MAGED2 →	+0.597	+0.054	<.001	<.001	3	5
LUAD	FMR1 →	+0.221	+0.038	<.001	<.001	3	5
PDAC	AFM →	+0.364	+0.040	.002	.006	3	5
PDAC	F12 →	+0.414	+0.049	.002	<.001	3	5
BRCA	TXNDC5 →	-0.426	-0.043	<.001	<.001	3	4
BRCA	C17orf75 →	+0.204	+0.034	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044830 vs MAGED2 — BRCA

Explore this scatter interactively →