Modulation by host of viral RNA genome replication

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPMT1, NCL, and NEK2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral RNA genome replication activity versus PTPMT1 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTPMT1 →	+0.217	+0.205	<.001	.009	3	3
COAD	NCL →	+0.388	+0.149	.002	.006	3	3
BRCA	NEK2 →	+0.739	+0.230	<.001	.003	3	3
BRCA	HJURP →	+0.672	+0.218	<.001	.005	3	3
BRCA	CKAP2L →	+0.576	+0.263	<.001	<.001	3	3
HNSC	BUB1 →	+0.802	+0.177	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044830 vs PTPMT1 — BRCA

Explore this scatter interactively →