Modulation by host of viral RNA genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATXN7L1, DBNL, and KALRN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATXN7L1 grouped by Modulation by host of viral RNA genome replication-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ATXN7L1 →	-1.063	-0.331	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	DBNL →	-1.118	-0.214	.003	.003	2	4
SKIN	KALRN →	-1.123	-0.607	<.001	.002	3	3
LARGE_INTESTINE	RUFY3 →	+0.997	+1.060	<.001	<.001	3	3
LARGE_INTESTINE	LRIG2 →	+0.799	+1.393	<.001	<.001	3	3
LARGE_INTESTINE	LRP6 →	+0.833	+0.975	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATXN7L1 by Modulation by host of viral RNA genome replication activity — UPPER_AERODIGESTIVE_TRACT

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