Modulation by host of viral RNA genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS27L, HLX, and PDE4DIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral RNA genome replication activity versus RPS27L in OVARY (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPS27L →	-1.205	-0.286	.003	.002	2	7
BLOOD_Leukemia	HLX →	-2.893	-1.094	<.001	<.001	3	5
STOMACH	PDE4DIP →	+1.435	+0.309	.006	.005	3	4
BLOOD_Leukemia	DDX50 →	+0.561	+0.782	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PROSER1 →	+0.583	+0.154	.005	.006	3	4
LUNG_NSCLC_LUAD	ARFGAP2 →	+0.777	+0.286	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044830 vs RPS27L — OVARY

Explore this scatter interactively →