Modulation by host of viral RNA genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral RNA genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX56, TMEM41B, and PNN, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral RNA genome replication activity versus DDX56 in LUNG_SCLC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DDX56 →	+0.835	+0.230	<.001	<.001	3	11
STOMACH	TMEM41B →	+1.024	+0.283	.007	.002	2	12
LUNG_NSCLC_LUAD	PNN →	+0.528	+0.246	<.001	<.001	3	11
LARGE_INTESTINE	FMR1 →	+1.143	+0.379	<.001	<.001	3	11
CNS	SRSF7 →	+0.521	+0.262	.001	<.001	3	9
OVARY	DKC1 →	+0.586	+0.271	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044830 vs DDX56 — LUNG_SCLC

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