Positive regulation by host of viral genome replication

Across TCGA patient cohorts, RNA activity of the Positive regulation by host of viral genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZFYVE1, EPM2AIP1, and HDGFL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral genome replication activity versus ZFYVE1 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZFYVE1 →	+0.227	+0.057	<.001	<.001	3	8
BRCA	EPM2AIP1 →	+0.467	+0.038	<.001	<.001	3	8
BRCA	HDGFL3 →	+0.464	+0.027	.001	<.001	3	8
PDAC	TRAP1 →	-0.358	-0.047	<.001	<.001	3	7
BRCA	DDX18 →	-0.335	-0.031	<.001	<.001	3	7
COAD	MRPL47 →	-0.274	-0.026	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044829 vs ZFYVE1 — CCRCC

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