Positive regulation by host of viral genome replication

Across TCGA patient cohorts, RNA activity of the Positive regulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL26, RCOR3, and EIF2D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral genome replication activity versus RPL26 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL26 →	+0.500	+0.161	.006	.005	3	5
LSCC	RCOR3 →	+0.435	+0.254	.002	<.001	3	4
GBM	EIF2D →	+0.252	+0.178	<.001	<.001	3	4
BRCA	LYSMD1 →	+0.501	+0.203	.002	.004	3	4
HNSC	CLK2 →	+0.508	+0.197	.003	.001	3	4
GBM	IPO9-AS1 →	+0.397	+0.127	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044829 vs RPL26 — OV

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