Negative regulation by host of viral genome replication

Across TCGA patient cohorts, RNA activity of the Negative regulation by host of viral genome replication pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC13D, SHARPIN_S165, and STAT1_S532, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral genome replication activity versus UNC13D in PDAC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UNC13D →	+0.339	+0.066	.003	.004	3	8
HNSC	SHARPIN_S165 →	+0.425	+0.075	<.001	<.001	3	7
PDAC	STAT1_S532 →	+1.190	+0.104	<.001	<.001	3	7
GBM	JUNB →	+0.424	+0.064	<.001	<.001	3	7
PDAC	PLAU →	+0.698	+0.079	<.001	<.001	3	7
GBM	PPP1R18_S224 →	+0.513	+0.074	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044828 vs UNC13D — PDAC

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