Negative regulation by host of viral genome replication

Across TCGA patient cohorts, RNA activity of the Negative regulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGAM5, E2F1, and CENPH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral genome replication activity versus PGAM5 in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PGAM5 →	+0.555	+0.194	<.001	.001	3	4
UCEC	E2F1 →	+0.971	+0.201	<.001	.007	2	4
UCEC	CENPH →	+0.449	+0.186	.001	.006	3	3
UCEC	CLEC9A →	-0.622	-0.193	.002	<.001	3	3
BRCA	LIG1 →	+0.331	+0.340	.002	<.001	3	3
BRCA	TACC3 →	+0.536	+0.347	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044828 vs PGAM5 — OV

Explore this scatter interactively →