Negative regulation by host of viral genome replication

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMPRSS4, SMIM22, and GMPPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMPRSS4 grouped by Negative regulation by host of viral genome replication-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMPRSS4 →	+4.045	+0.315	.003	.003	3	4
STOMACH	SMIM22 →	+4.222	+0.279	<.001	<.001	3	4
OVARY	GMPPA →	-0.498	-0.402	<.001	.007	3	4
LUNG_NSCLC_LUAD	BICDL1 →	+1.052	+0.448	.004	.007	3	4
SKIN	WDR44 →	-0.451	-0.248	.005	.002	3	4
BLOOD_Lymphoma	ZNF134 →	-1.423	-0.351	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMPRSS4 by Negative regulation by host of viral genome replication activity — STOMACH

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