Negative regulation by host of viral genome replication

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED1, SMC5, and SMC6, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral genome replication activity versus ZBED1 in LUNG_NSCLC_LUSC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZBED1 →	+1.236	+0.149	<.001	<.001	3	15
OVARY	SMC5 →	+1.037	+0.124	<.001	<.001	3	12
LUNG_NSCLC_LUSC	SMC6 →	+0.844	+0.136	.001	<.001	3	11
LARGE_INTESTINE	GEN1 →	+0.798	+0.088	<.001	<.001	3	11
URINARY_TRACT	ZC3H12A →	+1.628	+0.141	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	NOL8 →	+0.779	+0.120	<.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044828 vs ZBED1 — LUNG_NSCLC_LUSC

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