Modulation by host of viral genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFI27, IRF9, and MX1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral genome replication activity versus IFI27 in KIDNEY (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IFI27 →	+5.105	+0.145	<.001	<.001	3	16
LARGE_INTESTINE	IRF9 →	+2.038	+0.112	<.001	<.001	3	14
KIDNEY	MX1 →	+3.518	+0.112	.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	RSAD2 →	+2.927	+0.101	<.001	<.001	3	14
LUNG_NSCLC_LUSC	IFIT1 →	+2.816	+0.098	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	DDX60 →	+1.978	+0.085	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044827 vs IFI27 — KIDNEY

Explore this scatter interactively →