Modulation by host of viral genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB3, TMEM131L, and CARD14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral genome replication activity versus ERBB3 in LUNG_NSCLC_LUAD (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ERBB3 →	+2.313	+0.223	.001	.004	3	5
LUNG_NSCLC_LUSC	TMEM131L →	+1.134	+0.375	<.001	.008	3	5
BLOOD_Lymphoma	CARD14 →	+1.089	+0.207	.005	<.001	3	5
PANCREAS	PLXNB3 →	+1.753	+0.238	<.001	<.001	3	4
BLOOD_Lymphoma	BCAS4 →	-3.241	-0.184	<.001	<.001	3	4
LARGE_INTESTINE	ZNF862 →	+0.858	+0.121	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044827 vs ERBB3 — LUNG_NSCLC_LUAD

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