Mitotic G1/S transition checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic G1/S transition checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPN3, CCDC80, and FAP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G1/S transition checkpoint signaling activity versus EPN3 in LUAD (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EPN3 →	-0.483	-0.026	.002	<.001	3	6
OV	CCDC80 →	+0.966	+0.065	<.001	<.001	3	5
OV	FAP →	+1.061	+0.069	<.001	<.001	3	5
OV	GPX7 →	+0.471	+0.058	.003	<.001	3	5
OV	HIBCH →	-0.474	-0.049	.002	.001	3	5
OV	IKBIP →	+0.545	+0.065	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044819 vs EPN3 — LUAD

Explore this scatter interactively →