Mitotic G1/S transition checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic G1/S transition checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, NCKAP5, and CD302, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G1/S transition checkpoint signaling activity versus TYMS in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TYMS →	+0.530	+0.309	.003	.002	3	5
UCEC	NCKAP5 →	-0.419	-0.125	.009	.006	3	4
LUAD	CD302 →	-0.381	-0.169	.004	.008	3	4
BRCA	CAB39L →	-0.768	-0.274	<.001	.002	3	4
BRCA	VWA8 →	-0.495	-0.251	.002	.005	3	4
BRCA	ART4 →	-0.206	-0.214	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044819 vs TYMS — BRCA

Explore this scatter interactively →