Mitotic G1/S transition checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic G1/S transition checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYL1, SMC2, and CZIB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G1/S transition checkpoint signaling activity versus CRYL1 in HNSC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CRYL1 →	-0.614	-0.300	<.001	<.001	3	6
BRCA	SMC2 →	+0.518	+0.420	<.001	<.001	3	4
HNSC	CZIB →	-0.356	-0.254	<.001	<.001	3	4
GBM	MAPRE3 →	-0.530	-0.294	<.001	<.001	3	4
OV	DLG2_S28 →	-1.765	-0.287	<.001	<.001	3	4
GBM	RUNX1_T14 →	+0.579	+0.324	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044819 vs CRYL1 — HNSC

Explore this scatter interactively →