Mitotic G1/S transition checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic G1/S transition checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, MYORG, and MDM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Mitotic G1/S transition checkpoint signaling-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FDXR →	-0.886	-0.979	.007	.009	3	5
BREAST	MYORG →	+1.650	+0.271	.001	<.001	3	5
OVARY	MDM2 →	-1.100	-0.225	.001	.002	3	4
OVARY	RPS27L →	-1.737	-0.276	.001	.002	3	4
BREAST	RPS12 →	-0.782	-0.185	<.001	.003	3	4
OVARY	CDKN1A →	-3.316	-0.267	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Mitotic G1/S transition checkpoint signaling activity — SKIN

Explore this box plot interactively →