Mitotic G1/S transition checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic G1/S transition checkpoint signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGA3, POU2F1, and ADGRV1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGA3 grouped by Mitotic G1/S transition checkpoint signaling-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PGA3 →	+0.355	+0.199	<.001	.001	3	4
KIDNEY	POU2F1 →	+0.300	+0.282	.007	.004	3	4
LUNG_NSCLC_LUSC	ADGRV1 →	+0.110	+0.164	.009	.008	3	4
LUNG_SCLC	CLEC9A →	-0.260	-0.247	.001	.004	3	3
BREAST	CRYZ →	+0.135	+0.281	<.001	.002	3	3
SKIN	APBB1IP →	-0.195	-0.301	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGA3 by Mitotic G1/S transition checkpoint signaling activity — BLOOD_Myeloma

Explore this box plot interactively →