Mitotic G2/M transition checkpoint

Across TCGA patient cohorts, RNA activity of the Mitotic G2/M transition checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM4, ATAD5, and REXO5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G2/M transition checkpoint activity versus MCM4 in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM4 →	+0.793	+0.691	.001	.002	3	4
LSCC	ATAD5 →	+0.727	+0.644	.003	.001	3	4
LSCC	REXO5 →	+0.559	+0.658	.003	.003	3	4
BRCA	RFC3 →	+0.632	+0.411	.001	.007	3	4
BRCA	TMBIM1 →	-0.536	-0.415	.002	.007	3	4
LUAD	RNU6-216P →	+0.484	+0.588	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044818 vs MCM4 — LSCC

Explore this scatter interactively →