Mitotic G2/M transition checkpoint

Across TCGA cell cohorts, RNA activity of the Mitotic G2/M transition checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARHSP1, CXCL1, and KATNA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CARHSP1 grouped by Mitotic G2/M transition checkpoint-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CARHSP1 →	-0.844	-0.282	.001	.002	3	4
PANCREAS	CXCL1 →	+2.895	+0.253	.005	.005	3	4
BLOOD_Leukemia	KATNA1 →	+0.518	+0.190	.005	.001	3	4
LUNG_NSCLC_LUSC	CLCN7 →	-0.758	-0.176	.001	.007	3	4
SOFT_TISSUE	ZNF750 →	+0.117	+0.213	.001	.001	3	4
LARGE_INTESTINE	ZCCHC7 →	+0.522	+0.133	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CARHSP1 by Mitotic G2/M transition checkpoint activity — SKIN

Explore this box plot interactively →