Mitotic G2/M transition checkpoint

Across TCGA cell cohorts, RNA activity of the Mitotic G2/M transition checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASEF, EVPL, and KRT19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic G2/M transition checkpoint activity versus RASEF in LUNG_SCLC (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RASEF →	-2.272	-1.136	<.001	.001	3	4
OESOPHAGUS	EVPL →	-2.208	-1.321	.004	.003	3	4
OESOPHAGUS	KRT19 →	-4.578	-1.129	.004	.001	3	4
LUNG_SCLC	AGTRAP →	+1.196	+0.795	.005	.009	3	4
BONE	CYBRD1 →	+2.514	+1.359	.002	.002	3	4
PANCREAS	GSTO1 →	+0.706	+0.735	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044818 vs RASEF — LUNG_SCLC

Explore this scatter interactively →