Nucleophagy

Across TCGA patient cohorts, RNA activity of the Nucleophagy pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NPY_S82, COIL_S568, and ULK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleophagy activity versus NPY_S82 in UCEC (Pearson r = -0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPY_S82 →	-1.839	-1.584	<.001	<.001	3	3
BRCA	COIL_S568 →	-1.850	-1.775	.003	<.001	3	3
BRCA	ULK1 →	+0.349	+0.659	<.001	<.001	3	3
GBM	SIPA1L3_S401 →	-1.495	-1.311	<.001	<.001	3	2
OV	SPIDR →	-0.962	-0.232	<.001	.003	2	3
OV	TBC1D16 →	+0.959	+0.250	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044804 vs NPY_S82 — UCEC

Explore this scatter interactively →