Positive regulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Positive regulation by host of viral process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS5, RPL5, and RPS19, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral process activity versus RPS5 in LUAD (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS5 →	-0.167	-0.037	.001	.001	3	7
OV	RPL5 →	-0.171	-0.045	.007	.002	3	6
GBM	RPS19 →	-0.173	-0.049	.003	.001	3	6
LUAD	SEC23B →	-0.283	-0.045	<.001	<.001	3	6
OV	RPL11 →	-0.172	-0.039	.003	.009	3	6
OV	SERBP1 →	-0.288	-0.047	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044794 vs RPS5 — LUAD

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