Positive regulation by host of viral process

Across TCGA cell cohorts, RNA activity of the Positive regulation by host of viral process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMARCA4, APOE, and ACIN1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral process activity versus SMARCA4 in LUNG_NSCLC_LUAD (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMARCA4 →	+1.006	+0.259	.001	.001	3	13
LARGE_INTESTINE	APOE →	+1.613	+0.229	.001	.002	3	12
BONE	ACIN1 →	+0.692	+0.394	<.001	<.001	3	9
OVARY	SMARCB1 →	+0.787	+0.295	.003	.003	3	9
UPPER_AERODIGESTIVE_TRACT	PC →	+1.846	+0.225	<.001	<.001	3	9
CNS	PNN →	+0.559	+0.215	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044794 vs SMARCA4 — LUNG_NSCLC_LUAD

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