Negative regulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Negative regulation by host of viral process pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JUNB, WASL, and S100P, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral process activity versus JUNB in UCEC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JUNB →	+0.448	+0.094	<.001	<.001	3	7
OV	WASL →	-0.317	-0.047	.006	.002	3	7
GBM	S100P →	+1.325	+0.087	<.001	<.001	3	6
GBM	EHBP1_S1058 →	+0.765	+0.093	<.001	<.001	3	6
GBM	S100A8 →	+1.482	+0.080	<.001	<.001	3	6
BRCA	S100A9 →	+1.004	+0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044793 vs JUNB — UCEC

Explore this scatter interactively →