Negative regulation by host of viral process

Across TCGA patient cohorts, RNA activity of the Negative regulation by host of viral process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAPK10, AURKB, and H2BC18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation by host of viral process activity versus MAPK10 in LUAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAPK10 →	-0.582	-0.175	.002	.006	3	5
LUAD	AURKB →	+1.183	+0.245	<.001	<.001	3	5
LUAD	H2BC18 →	+0.731	+0.175	<.001	.002	3	5
LUAD	ASPM →	+0.989	+0.197	<.001	<.001	3	5
LSCC	MPHOSPH9 →	+0.372	+0.190	.004	.005	2	6
LSCC	TAF1A →	+0.296	+0.148	.005	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044793 vs MAPK10 — LUAD

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