Negative regulation by host of viral process

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT4, CLDN23, and TBC1D3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT4 grouped by Negative regulation by host of viral process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLAAT4 →	-3.374	-0.357	<.001	<.001	3	4
BLOOD_Myeloma	CLDN23 →	-0.089	-0.279	.004	<.001	3	4
LUNG_NSCLC_LUAD	TBC1D3B →	-0.802	-0.249	<.001	<.001	3	3
BONE	NAB2 →	+1.287	+0.426	.007	.002	3	3
BONE	TLR5 →	+1.139	+0.361	<.001	.003	3	3
BONE	GRK5 →	+2.595	+0.412	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT4 by Negative regulation by host of viral process activity — OVARY

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