Negative regulation by host of viral process

Across TCGA cell cohorts, RNA activity of the Negative regulation by host of viral process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL37, OPN1MW, and FYTTD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL37 grouped by Negative regulation by host of viral process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RPL37 →	+0.260	+0.230	.008	<.001	3	4
BLOOD_Leukemia	OPN1MW →	+0.294	+0.234	<.001	.006	3	4
OESOPHAGUS	FYTTD1 →	+0.153	+0.295	.001	.005	3	3
LARGE_INTESTINE	HINFP →	+0.226	+0.295	.005	.005	3	3
CNS	TUBA3C →	+0.353	+1.319	.001	<.001	3	3
CNS	CALCR →	+0.155	+0.825	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL37 by Negative regulation by host of viral process activity — BLOOD_Leukemia

Explore this box plot interactively →