Suppression of viral release by host

Across TCGA patient cohorts, RNA activity of the Suppression of viral release by host pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12B, IFIT5, and PML, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Suppression of viral release by host activity versus PPP1R12B in CCRCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPP1R12B →	+0.713	+0.055	<.001	<.001	3	7
GBM	IFIT5 →	+0.533	+0.065	<.001	<.001	3	7
GBM	PML →	+0.461	+0.048	<.001	<.001	3	7
CCRCC	CSRP1 →	+0.624	+0.035	<.001	.001	3	6
UCEC	AIDA →	+0.326	+0.070	<.001	<.001	3	6
CCRCC	FHL2 →	+0.681	+0.034	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044790 vs PPP1R12B — CCRCC

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